Translational Genomics

Research Program

Paediatric Cancer

Where we are

SJD Barcelona Children's Hospital

How to reach us

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Our Translational Genomics group merges scientific expertise in genomics and bioinformatics (with expertise and knowledge of specific genetic alterations) and the clinical context of paediatric solid tumours. We carry out research projects focusing on the study of the different genetic and epigenetic alterations underlying the clinical-pathological behaviour of paediatric tumours in order to identify new biomarkers and therapeutic targets that would constitute advances in the treatment and clinical management of these patients.

We have been an AGAUR consolidated research group (Government of Catalonia, reference 2017 SGR 1672) since 2014.

Research lines

  1. The study of the functional and clinical implications of DNA methylation changes.
  2. The development of epigenetic markers for the molecular classification of paediatric tumours.
  3. The development of a digital platform for the molecular classification of paediatric tumours.
  4. Epigenetic approaches to the pathogenesis of neuroblastoma.
  5. The development of treatment response biomarkers in neuroblastoma.

Scientific objectives

  1. To develop and validate (epi-)genetic biomarkers to improve the diagnosis, prognosis and monitoring of diseases.
  2. To investigate the possibility of using (epi-)genetic biomarkers in body fluids (liquid biopsy) of patients as non-invasive molecular markers for diagnosis, disease monitoring and treatment response.
  3. To develop tools for the implementation of new biomarkers in clinical practice.
  4. To investigate the functional and clinical implications of (epi-) genetic changes involved in the clinical-pathological behaviour of developmental tumours in order to identify potential therapeutic targets.

Area/Field of expertise

Analysis of specific genetic alterations in paediatric solid tumours. Clinical expertise in order to translate molecular data into a clinical opportunity.

Experience in the field of genomics and functional bioinformatics.

Development and validation of biomarkers for patient classification, prognosis determination and response to treatment of paediatric solid tumours.

Experience in designing our own analytical tools.

Group members

Last Publications

More Publications

Projects

Project name:
Desarrollo de clasificadores epigenéticos para el Cáncer Pediátrico (ECPC)
Leader
Cinzia Emilia Lavarino
Funding entities:
Instituto de Salud Carlos III (ISCIII)
Code
PI20/00519
Starting - finishing date:
2021 - 2023
Project name:
Platform of Epigenetic Classifiers for Childhood CAncer (PECA)
Leader
Cinzia Emilia Lavarino
Funding entities:
Fundació La Marató de TV3
Code
201921-30
Starting - finishing date:
2020 - 2023
Project name:
Método para la clasificación en subgrupos moleculares de pacientes con Meduloblastoma
Leader
Cinzia Emilia Lavarino
Funding entities:
Instituto de Salud Carlos III (ISCIII)
Code
PI17/00353
Starting - finishing date:
2018 - 2021
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Theses

  • Combined therapies for neuroblastoma based on the activation of the calcium sensing receptor
    Author
    Gonçalves Alves, Eliana Carolina
    Institution
    UNIVERSIDAD DE BARCELONA
    15/01/2021
  • Developmental Tumors, Epigenetics and microRNAs.
    Author
    Gomez Gonzalez, Soledad
    Institution
    UNIVERSIDAD DE BARCELONA
    21/09/2017
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