Marta García López
Jefe de Grupo
Research group
Research line:
New therapeutic strategies for High-risk neuroblastoma
Researcher Marta Garcia graduated in Biotechnology and Biochemistry in 2007 from the Universitat Autònoma de Barcelona (UAB) and obtained her PhD in Biochemistry, Molecular Biology and Biomedicine in 2013 (UAB) thanks to a scholarship from the Vall d'Hebron Research Institute (Barcelona). In 2016, the UAB itself awarded her an Extraordinary Doctoral Award for her thesis based on the generation and characterization of metastatic models in prostate cancer.
In 2014, she joined the New Therapeutic Strategies in Neuroblastoma Group of the Sant Joan de Déu Research Institute as a postdoctoral researcher under the direction of Dr. Carmen de Torres. Later, in 2019, she joined the Translational Genomics Group led by Dr. Cinzia Lavarino. In 2023, Dr. Garcia established her own line of research within the group as an Emerging Principal Investigator and is currently part of the group's management, together with Dr. Lavarino. Her scientific interest includes the development of new strategies to treat neuroblastic tumors, in particular, the most aggressive and chemoresistant ones that escape current standard treatment, but also in the study of new biomarkers for both diagnosis and prognosis focused on this type of tumor and other developmental tumors.
During her research career, she has co-authored numerous publications that have contributed to advancing the knowledge and understanding of developmental tumors through the identification of new biomarkers and classifiers, therapeutic targets, resistance mechanisms as well as characterization of the tumor microenvironment and metastatic niches, responding to unmet medical needs in pediatrics. His expertise focuses on advanced molecular laboratory techniques, analysis and interpretation of multi-omic data, molecular signatures, and functional assays (in vitro/animal models), always with a strong translational orientation.
Last Publications
- Figuerola-Bou E, Rios-Astorch C, Blanco E, Sanchez-Jimenez M, Táboas-Outón P, Fernandez-Isern G, Gomez-Gonzalez S, Muñoz-Aznar O, Castellano-Escuder P, Pérez-Jaume S, Garcia-López M, Prada-Varela E, Mateo-Lozano S, Riggi N, Avgustinova A, Lavarino C, Di Croce L, Sánchez-Molina S and Mora J KDM6 Demethylases Contribute to EWSR1::FLI1-Driven Oncogenic Reprogramming in Ewing Sarcoma CANCER RESEARCH . 85(22): 4485-4503.
- Gomez-Gonzalez S, Llano-Viles J, Garcia-López M, Garrido- García A, Suñol M, Lemos I, Pérez-Jaume S, Salvador-Marcos N, Gene-Olaciregui N, Galán RA, Santa-María López V, Pérez-Somarriba M, Castañeda-Heredia A, Hinojosa J, Winter U, Moreira FB, Lubieniecki F, Vazquez V, Mora J, Cruz-Martínez O, Morales-La Madrid A, Perera A and Lavarino C EpiGe: A machine-learning strategy for rapid classification of medulloblastoma using PCR-based methyl-genotyping iScience . 26(9): 107598-107598.
- García-Gerique L, Garcia-López M, Garrido- García A, Gómez-González S, Torrebadell-Burriel M, Prada-Varela E, Pascual-Pastó G, Muñoz-Aznar O, Pérez-Jaume S, Lemos I, Salvador-Marcos N, Vilà-Ubach M, Doncel-Requena A, Suñol M, Carcaboso AM, Mora J and Lavarino C MIF/CXCR4 signaling axis contributes to survival, invasion, and drug resistance of metastatic neuroblastoma cells in the bone marrow microenvironment BMC CANCER . 22(1): 669-669.
Projects
- Project name:
- Multi-ómica y cribado masivo de fármacos para el tratamiento dirigido del Neuroblastoma resistente al tratamiento
- Leader
- Cinzia Emilia Lavarino , Marta García López
- Funding entities:
- Instituto de Salud Carlos III (ISCIII)
- Code
- PI23/00120
- Starting - finishing date:
- 2024 - 2026
- Project name:
- Mecanismos de resistencia a la inmunoterapia anti-GD2 en neuroblastoma de alto riesgo
- Leader
- Cinzia Emilia Lavarino , Cristina Larrosa Espinosa
- Funding entities:
- Sociedad Española de Hematología y Oncología Pediátricas
- Code
- PCP00414
- Starting - finishing date:
- 2024 - 2025
- Project name:
- SGR 2022-2024_Grup de recerca en tumors del desenvolupament
- Leader
- Jaume Mora Graupera
- Funding entities:
- Agaur - Agència de Gestió d'Ajuts Universitaris i de Recerca
- Code
- 2021 SGR 01612
- Starting - finishing date:
- 2022 - 2025
More activities
-
#SeminarIRSJD · Identification of gene signatures and potential therapeutic targets for acquired chemotherapy resistance in neuroblastoma
Auditori J. Plaza · Hospital Sant Joan de Déu Barcelona