Neonatal Brain

Research Program

Neuroscience

Where we are

SJD Barcelona Children's Hospital

How to reach us

Related websites

The research mission of the Neonatal Brain group is to find answers to the questions that arise in clinical practice and to generate new knowledge on brain traumas/diseases during the foetal, perinatal or neonatal period that imply a major impact on the health and development of the infant. The ultimate goal of our research activity is to help reduce the health burden associated with foetal, perinatal or post-natal neurological diseases.

Our research is patient-centred and particularly focused on identifying clinical, biochemical, neurophysiological and neuroimaging diagnostic/prognostic biomarkers, as well as therapeutic aspects of acquired brain damage during birth or in the neonatal period. Our main lines of inquiry focus on perinatal hypoxic-ischaemic brain injury, cerebral arterial stroke, CNS maturation and acquired infection in the preterm infant as well as foetal brain damage of inflammatory-infectious aetiology.

Our group leader has been a member of CIBERER (Centre for Biomedical Network Research on Rare Diseases) since 2007.

Research lines

  1. Perinatal hypoxic-ischaemic encephalopathy (Principal investigator: A. García-Álix).
  2. Neonatal arterial ischaemic stroke (NAIS), from aetiological and pathogenic mechanisms to diagnostic-prognostic biomarkers (Principal investigator: A. García-Álix).
  3. Brain maturation, and how it could be affected by acquired brain injury (Principal investigator: T Agut).
  4. Intrauterine foetal infection, establishing inflammatory biomarkers in maternal, foetal and neonatal fluids to identify new diagnostic biomarkers and to predict neurodevelopmental risks (Principal investigator: Dr A. Alarcón).

Scientific objectives

  1. To develop and validate biochemical, neurophysiological, neuroimaging or metabolomic diagnostic-prognostic biomarkers for neurological diseases, expressed or with onset during foetal or neonatal life.
  2. To characterise the genes implicated in neonatal arterial ischaemic stroke.
  3. To develop and validate an automated tool for the classification of neonatal arterial ischaemic strokes which, after establishing the location and extent of lesions, would predict possible long-term neurological impairment, on a case-by-case basis, from the knowledge attained from lesion-behaviour mapping (voxel-based lesion-symptom mapping).
  4. To generate a morphometric atlas of brain development using ultrasound technology to qualify brain maturation, and to develop an atlas of cerebral vasculature using MRI.
  5. To characterise both phenotypic and neuroevolutionary aspects in neonates with acquired brain injuries.
  6. To estimate the health burden of the most prevalent neonatal neurological disorders.

Area/Field of expertise

The research carried out by our group forms part of the study of the clinical, biochemical, molecular and therapeutic aspects of neonatal neurological disorders originating during the foetal phase, at birth or during the neonatal period.

The group includes neonatologists specialising in neonatal neurology, who liaise closely with neuroneonatologists from other centres and in our area, and with neuropsychologists, neuropaediatricians, physicists and biochemists. We use state-of-the-art biochemical marker and neurophysiological monitoring and neuroimaging technology.

Group members

Last Publications

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Projects

Project name:
Estudio CRIB (Cribado de citomegalovirus congénito en recién nacidos sanos e ingresados - Barcelona)
Leader
Ana Alarcon Allen
Funding entities:
Instituto de Salud Carlos III (ISCIII)
Code
PI19/00095
Starting - finishing date:
2020 - 2022
Project name:
Contratos Rio Hortega
Leader
Alfredo Garcia-Alix Pérez
Funding entities:
Instituto de Salud Carlos III (ISCIII)
Code
CM18/00258
Starting - finishing date:
2019 - 2021
Project name:
Elaboración de un atlas morfométrico normalizado de la maduración cerebral del recién nacido prematuro y valoración del impacto de la patología cerebral en el proceso madurativo
Leader
Thais Agut Quijano
Funding entities:
Instituto de Salud Carlos III (ISCIII)
Code
PI18/00110
Starting - finishing date:
2019 - 2021
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Theses

  • Caracterización de pacientes pmm2-cdg: espectro fenotípico y correlación molecular
    Author
    Martinez Monseny, Antonio F
    Institution
    UNIVERSIDAD DE BARCELONA
    06/06/2019
  • Disfunción multiorgánica en el recién nacido con encefalopatía hipóxico-isquémica en la era de la hipotermia terapéutica
    Author
    Alsina Casanova, Miguel Mª
    Institution
    UNIVERSIDAD DE BARCELONA
    16/05/2018
  • Neuroprotección con hipotermia y Alopurinol (terapia combinada) en el daño cerebral hipóxico-isquémico. Valoración del daño cerebral y la reparación/regeneración neural en un modelo animal.
    Author
    Rodríguez Fanjul, Javier
    Institution
    UNIVERSIDAD DE BARCELONA
    11/01/2018
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