Immune and Respiratory Dysfunction in Critically Ill Children
Research Program
Leaders
Where we are
SJD Barcelona Children's Hospital
Related websites
SJD Barcelona Children's Hospital Our group concentrates its research on paediatric intensive care with special emphasis on clinical investigation into the immune response, the inflammatory response and respiratory impairment.
Research lines
- Systemic inflammatory response and diagnostic technology in the critically ill paediatric patient (Principal investigator: Iolanda Jordan).
- Acute respiratory failure in the critically ill paediatric patient (Principal investigator: Martí Pons Òdena).
Scientific objectives
- To define algorithms and clinical guidelines on the management of the systemic inflammatory response in patients with sepsis, infections caused by resistant pathogenic microorganisms or in complex chronic patients.
- To improve biomarker-guided antibiotic de-escalation in critically ill patients.
- To implement new devices for the prevention of nosocomial infections.
- To evaluate the effectiveness of devices (interfaces/respirators) in treating children with acute respiratory infections (ARI) in the general paediatric population and in patients with acute bronchiolitis.
- To generate knowledge about the effectiveness of high-flow oxygen therapy and non-invasive ventilation (NIV) in the critically ill patient with ARI and to facilitate prompt detection in the case of failure of this technique.
- To advance our knowledge on the optimisation of the mechanical ventilation weaning process in both acute and chronic patients.
Area/Field of expertise
Within our line of inquiry on the systemic inflammatory response, we have spearheaded three nationwide multicentre studies, one of which serves as a reference for nosocomial infections (ENVIN-PED registry) with the inclusion of over 1,800 patients per year. Regarding our research on biomarkers and sepsis, we have published various articles which corroborate the paradigm shift in the diagnosis and follow-up of antibiotic therapy in the critical paediatric patient. We were awarded three Health Research Fund (FIS) grants for this line of research, which has also led to the completion of five PhD theses and two more that are currently underway.
We are a group of clinicians and nursing staff offering a complementary approach to the issues raised by research in the field.
Our research into respiratory failure is conducted within the framework of research on the clinical and therapeutic aspects of respiratory care of the critically ill patient. Our main research goal is to investigate how new technologies could impact the management of respiratory failure in both the acute and chronic patient.
Our cohort studies on the effectiveness of NIV (including over 1,500 patients) is worth mentioning as this has helped consolidate our position as an international reference centre for this treatment in ICU patients, and also on a national scale, in the treating of patients on home ventilation.
Group members
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Aitor López González
Investigador
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Enrique Del Campo Garcia-Ramos
Profesional
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Roi Campos Rodriguez
Investigador
Last Publications
- Agüera T, Melé-Casas M, Molina MM, Pons-Odena M, Fernández de Sevilla-Estrach M, García-García JJ, Launes-Montana C and Monfort L Safety and effectiveness of bubble continuous positive airway pressure as respiratory support for bronchiolitis in a pediatric ward. EUROPEAN JOURNAL OF PEDIATRICS . 181(12): 4039-4047.
- LorenzoIzquierdo, David, Esquerda-Areste M, Palau F, Cambra-Lasaosa FJ and Grup Investigació en Bioética Ethics and Genomic Editing Using the Crispr-Cas9 Technique: Challenges and Conflicts NanoEthics . : .
- Fresán-Ruiz E, Pons-Tomás G, de Carlos-Vicente JC, Bustinza-Arriortua A, Slocker-Barrio M, Belda-Hofheinz S, Nieto-Moro M, Uriona-Tuma SM, Pinós-Tella L, Morteruel-Arizcuren E, Schuffelmann C, Peña-López Y, Bobillo-Perez S, Jordán-García I and On Behalf Of The Pediatric-Envin-Helics Study Group Device Exposure and Patient Risk Factors' Impact on the Healthcare-Associated Infection Rates in PICUs. CHILDREN-BASEL . 9(11): .
Projects
- Project name:
- ARDS in CHILDREN and ECMO initiation strategies impact on NEURO-DEVELOPMENT - ASCEND
- Leader
- Susana Segura Matute
- Funding entities:
- National Institute of Health (EEUU)
- Code
- SUBK00015894
- Starting - finishing date:
- 2020 - 2023
- Project name:
- Implicación de la microbiota bacteriana de la nasofaringe en el desarrollo de neumonía asociada a ventilación mecánica en la unidad de cuidados intensivos pediátricos. Estudio MiNoReP.
- Leader
- Iolanda Jordán García
- Funding entities:
- Instituto de Salud Carlos III (ISCIII)
- Code
- PI19/00106
- Starting - finishing date:
- 2020 - 2023
- Project name:
- Incapacitación legal en personas con transtorno mental grave: descripción del perfil clínico, neuropsicológico y elaboración de un modelo predictivo
- Leader
- Maria Elena Huerta Ramos
- Funding entities:
- Instituto de Salud Carlos III (ISCIII)
- Code
- PI17/00113
- Starting - finishing date:
- 2018 - 2022
Theses
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Millora en el diagnòstic i maneig de la pneumonia en el pacient pediàtric crític, mitjançant l’ús de l’ecografia pulmonar i la procalcitonina
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- Guitart Pardellans, Carmina
- Institution
- UNIVERSIDAD DE BARCELONA
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Infeccions relacionades amb l’assistència sanitària en el pacient pediàtric crític: Factors de risc i evolució, i estudi de resistències
- Author
- Girona Alarcon, Monica
- Institution
- UNIVERSIDAD DE BARCELONA
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Disseny i validació d´una eina pel reconeixement i estratificació precoç de la Sèpsia i Xoc Sèptic en Pediatria.
- Author
- Solé Ribalta, Anna
- Institution
- UNIVERSIDAD DE BARCELONA
News
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Relationship of environmental exposure to nitrogen oxide with the severity of rhinovirus infection
Researchers at Institut de Recerca Sant Joan de Déu (IRSJD) · SJD Barcelona Children's Hospital have found that exposure to higher concentrations of atmospheric nitrogen oxide in childhood is associated with greater severity of rhinovirus infection and a higher number of admissions to the Paediatric Intensive Care Unit.
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Researchers discover a key factor that predicts COVID-19 disease severity
A study led by Drs. Laia Alsina and Iolanda Jordan from the IRSJD evidences a key factor that predicts the severity of COVID-19: an alteration of the first immune response to SARS-CoV-2 infection, in key molecules in the anti-infective response. The study has been published in open access in the journal iScience.
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Measuring antibodies in saliva is a useful and easy strategy to detect SARS-CoV-2 infections
A study, published in BMC Medicine, performed through the Kids Corona platform from Sant Joan de Déu in collaboration with ISGlobal, shows that measuring antibodies in saliva is a useful and easy strategy to detect SARS-CoV-2 infections.