Immune and Respiratory Dysfunction in Critically Ill Children

Where we are

SJD Barcelona Children's Hospital

How to reach us

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Our group concentrates its research on paediatric intensive care with special emphasis on clinical investigation into the immune response, the inflammatory response and respiratory impairment.

Research lines

  1. Systemic inflammatory response and diagnostic technology in the critically ill paediatric patient (Principal investigator: Iolanda Jordan).
  2. Acute respiratory failure in the critically ill paediatric patient (Principal investigator: Martí Pons Òdena).

Scientific objectives

  1. To define algorithms and clinical guidelines on the management of the systemic inflammatory response in patients with sepsis, infections caused by resistant pathogenic microorganisms or in complex chronic patients.
  2. To improve biomarker-guided antibiotic de-escalation in critically ill patients.
  3. To implement new devices for the prevention of nosocomial infections.
  4. To evaluate the effectiveness of devices (interfaces/respirators) in treating children with acute respiratory infections (ARI) in the general paediatric population and in patients with acute bronchiolitis.
  5. To generate knowledge about the effectiveness of high-flow oxygen therapy and non-invasive ventilation (NIV) in the critically ill patient with ARI and to facilitate prompt detection in the case of failure of this technique.
  6. To advance our knowledge on the optimisation of the mechanical ventilation weaning process in both acute and chronic patients.

Area/Field of expertise

Within our line of inquiry on the systemic inflammatory response, we have spearheaded three nationwide multicentre studies, one of which serves as a reference for nosocomial infections (ENVIN-PED registry) with the inclusion of over 1,800 patients per year. Regarding our research on biomarkers and sepsis, we have published various articles which corroborate the paradigm shift in the diagnosis and follow-up of antibiotic therapy in the critical paediatric patient. We were awarded three Health Research Fund (FIS) grants for this line of research, which has also led to the completion of five PhD theses and two more that are currently underway.

We are a group of clinicians and nursing staff offering a complementary approach to the issues raised by research in the field.

Our research into respiratory failure is conducted within the framework of research on the clinical and therapeutic aspects of respiratory care of the critically ill patient. Our main research goal is to investigate how new technologies could impact the management of respiratory failure in both the acute and chronic patient.

Our cohort studies on the effectiveness of NIV (including over 1,500 patients) is worth mentioning as this has helped consolidate our position as an international reference centre for this treatment in ICU patients, and also on a national scale, in the treating of patients on home ventilation.

Group members

Last Publications

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Projects

Project name:
ARDS in CHILDREN and ECMO initiation strategies impact on NEURO-DEVELOPMENT - ASCEND
Leader
Susana Segura Matute
Funding entities:
National Institute of Health (EEUU)
Code
SUBK00015894
Starting - finishing date:
2020 - 2022
Project name:
Implicación de la microbiota bacteriana de la nasofaringe en el desarrollo de neumonía asociada a ventilación mecánica en la unidad de cuidados intensivos pediátricos. Estudio MiNoReP.
Leader
Iolanda Jordán García
Funding entities:
Instituto de Salud Carlos III (ISCIII)
Code
PI19/00106
Starting - finishing date:
2020 - 2022
Project name:
Incapacitación legal en personas con transtorno mental grave: descripción del perfil clínico, neuropsicológico y elaboración de un modelo predictivo
Leader
Maria Elena Huerta Ramos
Funding entities:
Instituto de Salud Carlos III (ISCIII)
Code
PI17/00113
Starting - finishing date:
2018 - 2022
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Theses

  • Sistemes de neurotransmissió en transtorns pediàtrics
    Author
    Cortés Saladelafont, Elisenda
    Institution
    UNIVERSIDAD DE BARCELONA
    17/09/2020
  • Bronquiolitis aguda: validació d'una escala de gravetat i ús de biomarcaddors per a la optimització del tractament.
    Author
    Alejandre Galobardes, Carme
    Institution
    UNIVERSIDAD DE BARCELONA
    19/06/2020
  • Confort y desconfort en el paciente crítico pediátrico, adaptación transcultural y validación de la escala comfort behavior scale
    Author
    Bosch Alcaraz, Alejandro
    Institution
    UNIVERSIDAD DE BARCELONA
    26/09/2019
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