Epilepsy and movement disorders in Pediatrics

Research Program


Where we are

SJD Barcelona Children's Hospital

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The Complex Epilepsies Research Group (CEReG) is dedicated to generating knowledge in the diagnosis and treatment of diseases that present with complex epilepsy or movement disorders. We focus on clinical and translational research, and use innovative technologies such as advanced neuroimaging, HD-EEG, HFOs, cerebral mapping, and genomics to develop diagnostic biomarkers in epileptic encephalopathies and developmental disorders, structural focal epilepsies that are drug-refractory, and movement disorders.

In addition, we collaborate on international projects for the development of personalized therapies in this group of pathologies. We have accreditations as a reference center for complex epilepsies in Catalonia (XUEC), CSUR in refractory epilepsies (CSUR-39), and in diseases that present with movement disorders (CSUR-53), and we are part of several European reference networks (ERNs) such as EpiCARE-Rare and Complex Epilepsies, coordinated by Alexis Arzimanoglou, and ERN-RND (Rare Neurological Disorders). We are also members of CIBERER and recognized by AGAUR as a consolidated research group in Neuroscience.

Research lines

  1. Diseases with Movement Disorder (PI: D. Ortigoza).
  2. Neonatal seizures and epileptic and developmental encephalopathies of early onset of genetic and neurometabolic origin (PI: C. Fons).
  3. Structural focal epilepsies (PI: J. Aparicio).
  4. Epilepsy and sleep, comorbidity of sleep disorders (PI: O. Sans).

Scientific objectives

  1. Phenotypic and genotypic characterisation of diseases with movement disorders and study of diagnostic biomarkers.
  2. Study of prognostic and diagnostic biomarkers and design of personalised therapies in neonatal seizures and epileptic encephalopathies of genetic and neurometabolic origin.
  3. Study and development of pre-surgical diagnostic evaluations and analysis of diagnostic, therapeutic and prognostic biomarkers in structural focal epilepsies.
  4. Study of cardiorespiratory changes during sleep in children with epilepsy and their relationship with epileptic seizures.

Area/Field of expertise

The field of epilepsy research encompasses a variety of specializations, including:

  • Analysis of the brain bioelectrical signal, both at the level of surface electrodes (scalp) and deep electrodes (surgically implanted at intracerebral level). The characteristics of pathological electrical rhythms and their relationship with the ictal onset zone and the post-surgical outcome of epilepsy will be determined in an automated way.
  • Evaluation of neuroimaging (structural and functional) in the pre-surgical study of epilepsy. Qualitative and quantitative assessment of the alterations observed in the different neuroimaging tests (structural and functional brain MRI, ictal and interictal SPECT, brain PET), and correlation with ictal symptomatology, electroencephalographic and neuropsychological findings, and post-surgical outcomes.
  • Aetiological assessment of epilepsy, especially at the genetic and metabolic level. These disorders will be analysed, including an electro-clinical-radiological description, using structured video-electroencephalography, neuropsychology and neuroimaging protocols.

Group members

Last Publications

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Project name:
PFNR0177_Seguridad y eficacia de la estimulación transcraneal directa de corriente continua (tDCS) en pacientes pediátricos con enfermedades neuropsiquiátricas.
Maria Alejandra Climent Perin
Funding entities:
Fundació Ramón Areces, Fundació Privada per a la Recerca i la Docència Sant Joan de Déu - FSJD, Climent Perin, Maria Alejandra
FSJD-NeuroHoop-2023 (R)
Starting - finishing date:
2023 - 2025
Project name:
Mapas de conectividad funcional cerebral y neurodesarrollo en pacientes con epilepsias pediátricas de debut precoz. EPI-NeuroMAPS
Maria del Carmen Fons Estupiña
Funding entities:
Torrons Vicens SL
Starting - finishing date:
2023 - 2024
Project name:
El análisis de la conectividad cerebral como herramienta para evaluar los trastornos neuroconductuales y de regulación emocional (EpilETRE.net)
Alexis Arzimanoglou
Funding entities:
Instituto de Salud Carlos III (ISCIII)
Starting - finishing date:
2022 - 2024
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