Elisabet Figuerola Bou
Characterization and relevance of the epigenetic environment in the development of Ewing’s sarcoma
Researcher Elisabet Figuerola Bou graduated in Biomedical Sciences in 2013 from the University of Barcelona and in 2014 she obtained a master's degree in Genetics and Genomics from the same university. In May 2014, she won the first prize for young researchers Gemma Rossell i Romero from the University of Barcelona for her undergraduate work on DNA methylation in cancer in the laboratory of Dr Manel Esteller.
In 2014, she joined Dr Jaume Mora's Developmental Tumors Laboratory at the Sant Joan de Déu Developmental Tumors Laboratory as a predoctoral researcher, where she developed her doctoral dissertation on the role of epigenetics in the development of Ewing's sarcoma. In December 2019 she obtained a PhD in Biomedicine from the University of Barcelona, led by Dr Jaume Mora and Dr Sara Sánchez-Molina. She has also trained in animal experimentation, scientific outreach and bioinformatics analysis for biomedical research.
She is currently working as a postdoctoral researcher in the Sarcomas and Histiocytosis group studying in depth key epigenetic targets for the development and maintenance of Ewing's sarcoma.
Professional network profiles
- García-Domínguez DJ, Hajji N, López-Alemany R, Sánchez-Molina S, Figuerola-Bou E, Morón Civanto FJ, Rello-Varona S, Andrés-León E, Benito A, Keun HC, Mora J, Tirado ÓM, de Álava E and Hontecillas-Prieto L Selective histone methyltransferase G9a inhibition reduces metastatic development of Ewing sarcoma through the epigenetic regulation of NEU1. Oncogene . 41(18): 2638-2650.
- García-Domínguez DJ, Hajji N, Sánchez-Molina S, Figuerola-Bou E, de Pablos RM, Espinosa-Oliva AM, Andrés-León E, Terrón-Camero LC, Flores-Campos R, Pascual-Pastó G, Robles MJ, Machado I, Llombart-Bosch A, Magagnoli G, Scotlandi K, Carcaboso AM, Mora J, de Álava E and Hontecillas-Prieto L Selective inhibition of HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the EWSR1 promoter in Ewing sarcoma. Oncogene . 40(39): 5843-5853.
- Sánchez-Molina S, Figuerola-Bou E, Blanco ME, Sánchez-Jiménez M, Táboas P, Gomez-Gonzalez S, Ballaré C, García-Domínguez DJ, Prada-Varela E, Hontecillas-Prieto L, Carcaboso AM, Tirado ÓM, Hernandez-Muñoz MI, de Álava E, Lavarino C, Di Croce L and Mora J RING1B recruits EWSR1-FLI1 and cooperates in the remodeling of chromatin necessary for Ewing sarcoma tumorigenesis. Science Advances . 6(43): 3058.
A study with Dr. Jaume Mora (IRSJD) team participation and led by the Molecular Pathology of Sarcomas group of the Seville Institute of Biomedicine (IBiS) has described that the G9a protein would be associated with the development of metastases in Ewing's Sarcoma. Therefore, the overexpression of this protein would indicate an adverse prognosis.