
Sara Sánchez Molina
Investigador
Research group
Sara Sánchez-Molina holds degrees in Chemistry (1999) and Biochemistry (2001) from the University of Barcelona. From early 2002 to late 2006, she completed her doctoral thesis under the supervision of Dr. Marian Martínez Balbás in the Molecular Signaling and Chromatin group at the Institute of Molecular Biology of Barcelona (CSIC). During this period, she studied the role of histone modifications in cellular transformation induced by the Ras oncogene.
In 2007, she joined the Chromatin Dynamics group led by Dr. Peter Becker at the Adolf Butenandt Institut, Ludwig Maximilian University of Munich (Germany), where she was employed as a postdoctoral researcher until 2011. During this time, she focused on elucidating the role of ISWI family chromatin remodeling complexes and their function in signaling DNA damage induced by X-rays, UV rays, and replication stress.
In 2013, she joined the Sarcoma and Neuroblastoma group as a postdoctoral researcher. Within this group, she has developed various lines of research focused on the analysis of chromatin and the Polycomb complex in Ewing's sarcoma and rhabdomyosarcoma. She currently leads the Pediatric Sarcoma Epigenetics team. Her main objective is to propose new treatments for pediatric patients with sarcomas with a poor prognosis based on an in-depth understanding of the dysregulation of molecular mechanisms associated with chromatin. She has supervised seven doctoral theses and has participated in various national and international projects and conferences.
Last Publications
- Figuerola-Bou E, Rios-Astorch C, Blanco E, Sanchez-Jimenez M, Táboas-Outón P, Fernandez-Isern G, Gomez-Gonzalez S, Muñoz-Aznar O, Castellano P, Pérez-Jaume S, Prada-Varela E, Mateo-Lozano S, Riggi N, Avgustinova A, Lavarino C, Di Croce L, Sánchez-Molina S and Mora J KDM6 demethylases mediate EWSR1-FLI1-driven oncogenic transformation in Ewing Sarcoma Biorxiv . : .
- Sánchez-Molina S, Figuerola-Bou E, Sánchez-Margalet V, de la Cruz-Merino L, Mora J, de Álava Casado E, García-Domínguez DJ and Hontecillas-Prieto L Ewing Sarcoma Meets Epigenetics, Immunology and Nanomedicine: Moving Forward into Novel Therapeutic Strategies Cancers . 14(21): .
- Molnar C, Reina J, Herrero A, Heinen JP, Méndiz V, Bonnal S, Irimia M, Sanchez-Jimenez M, Sánchez-Molina S, Mora J and González C Human EWS-FLI protein recapitulates in Drosophila the neomorphic functions that induce Ewing sarcoma tumorigenesis PNAS Nexus . 1(4): 222.
Projects
- Project name:
- Epigenetic disruption of EWSR1-FLI1 condensates
- Leader
- Sara Sánchez Molina
- Funding entities:
- Bone Cancer Research Trust
- Code
- 10024
- Starting - finishing date:
- 2025 - 2028
- Project name:
- Disrupción de enhancers: la nueva generación de terapia epigenética en el sarcoma de Ewing
- Leader
- Jaume Mora Graupera, Sara Sánchez Molina
- Funding entities:
- Instituto de Salud Carlos III (ISCIII)
- Code
- PI24/00804
- Starting - finishing date:
- 2025 - 2027
- Project name:
- Influencia del contexto epigenético en la edad como factor pronóstico en Ewing Sarcoma
- Leader
- Jaume Mora Graupera
- Funding entities:
- Instituto de Salud Carlos III (ISCIII)
- Code
- PI20/00179
- Starting - finishing date:
- 2021 - 2023
News
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Scientists at IRSJD and IRB Barcelona develop a study model for Ewing sarcoma in the Drosophila fly
This novel model has come about from a close collaboration between the laboratories headed by Dr. Jaume Mora at Institut de Recerca Sant Joan de Déu (IRSJD) and SJD Barcelona Children’s Hospital, and Dr. Cayetano Gonzalez at the Institute for Research in Biomedicine (IRB Barcelona). The work has been published in the journal PNAS Nexus.
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Describe an epigenetic protein associated with the metastatic process in Ewing's Sarcoma
A study with Dr. Jaume Mora (IRSJD) team participation and led by the Molecular Pathology of Sarcomas group of the Seville Institute of Biomedicine (IBiS) has described that the G9a protein would be associated with the development of metastases in Ewing's Sarcoma. Therefore, the overexpression of this protein would indicate an adverse prognosis.
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Gene crucial for growth of Ewing sarcoma uncovered
Researchers at the Institut de Recerca Sant Joan de Déu in collaboration with those at Centre for Genomic Regulation have discovered that RING1B is a critical gene for the development of Ewing sarcoma, a rare type of developmental cancer that presents in bones and soft tissues.
More activities
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Defensa tesi doctoral: Pablo Táboas Outón
Auditori Plaza · Hospital Sant Joan de Déu and online
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Defensa tesi doctoral: María Sánchez Jiménez
Auditori Plaza · Hospital Sant Joan de Déu and online