Webinar IRISCAT · "Pleiotropy & human complex disease"
- Dr. Gerard Muntané · Researcher at Institut d'Investigació Sanitària Pere Virgili (IISPV).
Complex diseases have a highly polygenic architecture with a large genetic overlap with other diseases/traits. The underlying genetic architecture of common diseases suggests that human diseases are far more linked than previously expected, suggesting substantial pleiotropy between contributing genetic variants, frequently showing opposite directions. It is likely that disease risk alleles can affect patients through intricate pleiotropic relationships increasing or reducing the risk of comorbid diseases, or vice versa, or even affecting their lifespans.