Projectes

Codi

101161079

Investigador/a principal

Arnau Valls Esteve

Rol

Coordinador

Any d'inici

2024

Any de finalització

2026

Import total

247582,16€

Objectius

Although children and adolescents make up nearly 25% of the world's population, their health needs are not adequately addressed, making them a vulnerable population. New medical products reach the paediatric market 5 to 10 years later than the adult population, forcing healthcare professionals to adapt products designed for adults. In addition, around 75% of rare diseases affect paediatric patients, as most of them present at an early age. These children take an average of 7.5 years to receive an accurate diagnosis, after seeing 4 general practitioners, 4 specialists and being misdiagnosed 3 times.
To improve these disparities in paediatric innovation, the Sant Joan de Déu Barcelona Children's Hospital created, in 2020, i4KIDS: the paediatric innovation hub. Over the last 3 years, i4KIDS has gained in-depth experience and knowledge in the acceleration of medical devices for the paediatric population, becoming a reference at regional level, from the identification of unmet needs to clinical validation for certification.
With around 75% of rare diseases occurring in childhood, i4KIDS aims to create i4KIDS 4RARE: an accelerator to support the development of orphan medical devices for paediatric patients. To demonstrate the capabilities of i4KIDS 4RARE, 2 specific programmes will be implemented:
- Validation and valorisation 4RARE programme with 2 paediatric use cases: (1) Patient monitoring during complex surgery in children with congenital heart disease (2) Home rehabilitation platform for children with Spinal Muscle Atrophy (SMA).
- Challenge-based 4RARE programme from 2 different perspectives: (1) The ERN perspective on paediatric rare epilepsy (Epicare) (2) From the perspective of industry.
Through the implementation of i4KIDS 4RARE, we will support pioneering solutions to improve the quality of life of children and families affected by rare diseases, raise awareness of the challenges and share the many opportunities and high-impact innovations.

Codi

101144544

Investigador/a principal

Paula Cristobal Narvaez

Rol

Participant

Any d'inici

2024

Any de finalització

2026

Import total

239338€

Objectius

(EM)POWER YOU(TH) is an innovative model for combating Islamophobia based on changing narrative frameworks by including young Muslims in the European public debate. Through a co-working system, together with young Muslims aged 18-30, we will analyse islamophobic and xenophobic discourses that target this social group and their communities. Subsequently, we will co-create new narrative frameworks to combat Islamophobia by seizing the public debate. Finally, we will train young people to help them to become opinion leaders and (EM)POWER YOU(TH) will facilitate their access to media and other spaces of influence. We propose resources and tools for the empowerment of these target groups to identify intra-group discriminatory practices and generate internal transformation processes and progress in equality.

Codi

101140815

Investigador/a principal

Marcos Febas Fernández

Rol

Participant

Any d'inici

2024

Any de finalització

2026

Import total

169581,41€

Objectius

N.E.A.R. to Guardians general objective is to increase the networking, exchange of good practices, and knowledge sharing, amongst various relevant actors across the EU on reinforcing effective guardianship with the aim of ensuring full access of basic rights and
potential of UASCs, focusing in key areas for integration such as housing, working inclusion and education, in 5 EU Member States
(Italy, Spain, Greece, Slovenia and Belgium). Target group will be the guardians of UASCs and the relevant actors providing support to guardians, such as public administrations
and institutions, ministries/authorities for children or social affairs, international organisations, social services responsible for housing,
labour market integration, education.
Main project activities will be: a collection and exchange of good practices, including study visits, on effective guardianship to UASCs in the key areas of housing, labour market integration, education, in 5 MS (WP2); a training curriculum focused in the key areas
mentioned above, and an e-learning platform and digital library for guardians and relevant stakeholders (WP3); 4 local working tables (in Italy, Greece, Spain, Slovenia) to consolidate methodologies and strengthening local networks, and the creation of a “Sister cities
Network” and a “Manifesto for Inclusion” which will ensure the continuation of the comparison and exchange activities over the years. A set of tailor-made awareness raising activities, advocacy, dissemination and communication measures (WP5) will be carried
out to maximize the project results.
The expected impacts are: a reinforced capacity of institutions involved in reception, protection and guardianship, and of guardians, in protection of UASCs; a better dialogue among different groups of society, institutions and local authorities on effective
guardianship; an increased level of inclusion and protection of young migrants in host EU society; increased visibility of guardianship across all MS.

Codi

PI23/00053

Investigador/a principal

Maria Dolores Gómez Roig

Rol

Individual

Any d'inici

2024

Any de finalització

2026

Import total

140000€

Objectius

Introducción:
El consumo de alcohol en el embarazo se asocia a efectos adversos perinatales (retraso de crecimiento fetal-RCF) y a alteraciones del neurodesarrollo (Trastorno del Espectro Alcohólico Fetal-TEAF) que se diagnostican de manera tardía en la infancia. Se desconocen los mecanismos biológicos que median la exposición prenatal al alcohol con sus potenciales efectos adversos pre y postnatales.

Objetivo:
Determinar si el consumo prenatal de alcohol produce cambios moleculares (longitud del telómero-LT, contenido de DNA mitocondrial -mitDNA, y metilación del DNA a lo largo del epigenoma-DNAm) en placenta y/o sangre de cordón umbilical (SCU), estableciendo así una posible etiopatogenia con el RCF y los TEAF asociados.

Metodología:
Se trata de un proyecto de continuidad de tres proyectos previos: EMOTIVE (PI17/00105), EMOTIVE PLUS (PI20/00490) y BiSC (PI17/01142 - AirPLASM Project y PI20/00190 - ALMA project). EMOTIVE y EMOTIVE PLUS son estudios que evalúan una intervención prenatal en la disminución del consumo de alcohol. BiSC estudia el impacto de la contaminación ambiental en el embarazo sobre la salud infantil.
Este proyecto evaluará 100 consumidoras de alcohol y 600 no consumidoras. En las tres cohortes, a las participantes se les ha realizado una ecografía a las 32-34 semanas (crecimiento fetal y Doppler maternofetal). En el momento del parto se ha recogido pelo materno para determinar metabolitos del alcohol (etilglucorónido), así como SCU y muestras placentarias. A los 18 meses de vida, se ha evaluado el neurodesarrollo de los bebés mediante la escala Bayley-III.
En este estudio, se analizará la LT, el mitDNA y el DNAm en placentas y en SCU y se relacionarán con el consumo de alcohol, la función placentaria y el neurodesarrollo postnatal.

Impacto:
Conocer los mecanismos moleculares permitirá establecer biomarcadores precoces de diagnóstico, y así prevenir los efectos adversos del consumo de alcohol durante el embarazo en la población expuesta.

Codi

PT23/00002

Investigador/a principal

Cristina Jou Muñoz

Rol

Individual

Any d'inici

2024

Any de finalització

2026

Import total

448920€

Objectius

ISCIII_Cristina Jou

Codi

101131809

Investigador/a principal

Josep Maria Haro Abad

Rol

Participant

Any d'inici

2024

Any de finalització

2026

Import total

146377,5€

Objectius

The INTEGRATE-LMedC consortium will develop a new concept to guide and support decision-making for the next-generation research infrastructure (RI) to facilitate efficient utilization and harmonization of large medical cohorts (LMedC), and to accelerate scientific and medical breakthroughs in Europe and beyond. Achievement of the ambitious objectives will only be possible through the integration of 11 highly interdisciplinary partners including established ERIC / ESFRI infrastructures such BBMRI, ECRIN, EIRENE and EBRAINS with unique expertise in conceptualizing and implementing European RIs. The partners will generate a gap analysis to identify what is missing of cohort data and samples, RI tools and services, quality measures, governance models, user needs and the barriers for efficient utilization of these cohorts and RI, including ethical and legal frameworks. To identify IT technologies and architecture for suitable data stewardship and long-term availability of European RIs, the partners will prepare for a feasibility study for federated data analysis of LMedC. The feasibility study will be based on two examples of use-cases: one stroke case using data from medical health registry data and one case using data from longitudinal population-based studies with different technical, legal, and ethical challenges. To ensure availability of data and samples related to existing and future LMedC studies and their re-use for secondary research, the partners will develop a concept outline including a governance plan and guiding principles for data access policies and data protection policy, whilst considering the FAIR principles and ELSI issues. An overarching RI concept to manage, integrate, and sustain LMedC studies will be developed, including an initial financial and operational plan for the implementation of the new RI outlining new services and access opportunities for the research community.

Codi

AC23_2/00021

Investigador/a principal

Eulalia Baselga Torres

Rol

Coordinador

Any d'inici

2024

Any de finalització

2026

Import total

233297,5€

Objectius

ISCIII_Eulalia Baselga

Codi

AC23_2/00020

Investigador/a principal

Eulalia Baselga Torres

Rol

Participant

Any d'inici

2024

Any de finalització

2026

Import total

59166,66€

Objectius

Las malformaciones capilares (MC) afectan a 3 /1000 recién nacidos. El 6% de los pacientes con MC frontal sufren el síndrome de Sturge-Weber (SWS), con manifestaciones neurológicas y oculares. Está causada por una mutación activadora somática en el gen GNAQ (GNAQR183Q) en las células endoteliales (CE). No hay terapia dirigida porque no se comprende la biología de su patogénesis. La hipótesis de 'RepairQ' es que la mutación GNAQR183Q en las CE durante la angiogénesis del desarrollo afecta la formación de redes capilares adecuadas. Las CE mutadas inducen capilares dilatados y tortuosos, con defectos persistentes en la función vascular. Para comprender los efectos de la activación de GNAQ, se desarrollarán modelos preclínicos adaptados e innovadores que capturen la naturaleza dinámica y el inicio de la patogénesis de las MC. Se propone una caracterización de las manifestaciones clínicas de los pacientes para establecer protocolos diagnósticos efectivos y su manejo. Se emplearán tecnologías de vanguardia en biología vascular, genética de ratones, biología celular y señalización, y observaciones clínicas. Los objetivos específicos incluyen la creación de pautas clínicas y un atlas molecular para las MC con GNAQR183Q, la identificación de las vulnerabilidades celulares y moleculares de GNAQR183Q en las CE in vitro, la modelización y caracterización de las MC con GnaqR183Q in vivo, y la implementación de una terapia dirigida para reparar el endotelio con GNAQR183Q. 'RepairQ' une a cuatro investigadores principales con experiencia complementaria. La colaboración estrecha entre laboratorios permitirá avances técnicos y conceptuales más allá de cualquier laboratorio individual. La propuesta se basa en estudios en humanos para garantizar que los hallazgos sean clínicamente relevantes para las CM relacionadas con GNAQ. Esta comprensión de las MC conlleva una mejora atención al paciente y abre vías de conocimiento sobre la regulación molecular del desarrollo vascular.

Codi

PI23/00049

Investigador/a principal

Carmen Muñoz Almagro

Rol

Individual

Any d'inici

2024

Any de finalització

2026

Import total

115000€

Objectius

ISCIII_Carmen Muñoz

Codi

PT23/00087

Investigador/a principal

Arnau Valls Esteve

Rol

Individual

Any d'inici

2024

Any de finalització

2026

Import total

374854€

Objectius

ISCIII_Arnau Valls