Projectes

Codi

AEI-010500-2025-128

Investigador/a principal

Elena Codina Sampera

Rol

Participant

Any d'inici

2025

Any de finalització

2026

Import total

18399€

Objectius

Ministerio de Industria y Turismo_Codina Sampera, Elena

Investigador/a principal

Maria Diez Juan

Rol

Participant

Any d'inici

2025

Any de finalització

2026

Import total

9650€

Objectius

European Commission_Aritz Aranbarri

Codi

PMP24/00024

Investigador/a principal

Guerau Fernandez Isern

Rol

Participant

Any d'inici

2025

Any de finalització

2026

Import total

55539€

Objectius

ISCIII_Fernández Isern, Guerau

Codi

101219053

Investigador/a principal

Begoña Nafria Escalera, Esther Lasheras Soria

Rol

Participant

Any d'inici

2025

Any de finalització

2028

Import total

63101,75€

Objectius

European Commission_Begonya Nafria

Codi

101214326

Investigador/a principal

Andrés Morales La Madrid

Rol

Participant

Any d'inici

2025

Any de finalització

2030

Import total

231875€

Objectius

European Commission_Andres Morales

Codi

2025 FI-1 00345

Investigador/a principal

Judith Usall i Rodié

Rol

Individual

Any d'inici

2025

Any de finalització

2028

Import total

78126,55€

Objectius

AGAUR_Usall i Rodié, Judith

Codi

330301961

Investigador/a principal

Andrés Morales La Madrid

Rol

Participant

Any d'inici

2025

Any de finalització

2026

Import total

180175€

Objectius

European Commission_Andres Morales

Codi

2024 DI 00150

Investigador/a principal

Francisco García Cuyás

Rol

Individual

Any d'inici

2025

Any de finalització

2028

Import total

22800€

Objectius

AGAUR_García Cuyàs, Francesc

Codi

202414-30

Investigador/a principal

Maria Dolores Gómez Roig

Rol

Coordinador

Any d'inici

2025

Any de finalització

2028

Import total

100427,5€

Objectius

There is more and more evidence that indicates that the environment that surrounds us, from the moment we are conceived, but also during our childhood and adolescence [that is, how we eat and live, what our living habits are, or what the air is like that we breathe] influences our health, and more specifically our sexual and reproductive health.
Our objective is to investigate whether there is a relationship between our diet, our lifestyle habits (alcohol and tobacco consumption), the air we breathe or the pollutants to which we are exposed, during conception, childhood and early adulthood, with sexual and reproductive health. To this end, 4,000 pregnant women and their newborn children, from
different regions of Spain, have voluntarily provided information about their diet, habits and lifestyle, etc., during the first 14- 18 years of their children's lives. The participants have also donated biological samples (blood, urine, milk, etc.) where different clinical variables have been measured (blood count, pollutants, etc.). The quality of the water they drank and the
quality of the air they breathed are also known.
Now that the children are teenagers (or almost adults), they are between 16-22 years old, we propose to contact the
participants again to find out what their sexual and reproductive health is. We will perform a physical examination, and we
will ask how and when the onset of puberty occurred, we will evaluate ovarian function in girls, we will analyze the seminal
quality of boys, and we will study if they have gynecological pathologies such as endometriosis. We want to analyze, using
all the information available, both the information collected during the last 18 years, as well as the new information
generated with this project that we request, if it is possible to prevent the reproductive health problems that are detected.
The data generated will also improve clinical practice but will transcend this area, since it will be published on social
networks and different general media.
Strengthening scientific knowledge is the only way to make correct decisions, since it allows us to fill in the information
gaps that still exist and update scientific data for the development of appropriate environmental policies.

Codi

202417/30

Investigador/a principal

Lourdes Ibañez Toda

Rol

Coordinador

Any d'inici

2025

Any de finalització

2028

Import total

124200€

Objectius

Background: The pathophysiology of polycystic ovary syndrome (PCOS) is unclear, but reflects alterations in the homeostatic feedback mechanisms between the gonads, adipose tissue, and hypothalamic brain circuits. The development of genetic animal models of human PCOS provides valuable insight into the pathogenesis of the disorder. Objectives: Elucidate the pathogenesis of PCOS in a fly model (Drosophila melanogaster) with a PCOS-like phenotype and identify novel biomarkers for its early diagnosis in humans:
Aim 1. Characterization of the cellular/endocrine interactions between the neuroendocrine-adipose-gonadal axis in the fly model.
Aim 2. Contribution of adipose tissue to the PCOS-like phenotype.
Aim 3. Unraveling new (epi)genetic and metabolic markers in adolescents and young adult women (AYAs) with
PCOS.
Methods: In the animal model, single-cell transcriptomics and epigenomics (scRNA-seq, scATAC-seq) and lipidomics in larval neuroendocrine organ, gonads and adipose tissue, and analysis of the inter-organ network involved in PCOS, followed by nutritional/pharmacological interventions. In humans, in silico analysis and clinical study in AYAs with PCOS vs healthy controls to validate the biomarkers identified in the fly model. Expected results: Our project will help elucidate the cell-autonomous/hormonal mechanisms involved in PCOS. This will translate into clinical research by identifying potential biomarkers for early diagnosis of PCOS.