Sara Sánchez Molina
Investigador
Research group
Sara Sánchez-Molina holds a degree in Chemistry (1999) and Biochemistry (2001) from the University of Barcelona. From early 2002 until late 2006, she carried out her doctoral thesis under the supervision of Dr Marian Martínez Balbás in the Molecular Signalling and Chromatin group at the Institute of Molecular Biology of Barcelona (CSIC). During this period, she studied the role of histone modifications in cellular transformation induced by the Ras oncogene, gaining knowledge in molecular biology and epigenetics of cancer.
In 2007, she joined the Chromatin Dynamics group led by Dr Peter Becker at the Adolf Butenandt Institute of the Ludwig Maximilians University in Munich (Germany), where she was employed as a postdoctoral researcher until 2011. During this time, she focused on elucidating the role of the chromatin remodelling complexes of the ISWI family and their function in signalling DNA damage induced by X-rays, UV, and replicational stress.
As a postdoctoral researcher in 2013, she joined the "Sarcomas and Histiocytosis" group. Within this group, she has developed different lines of research focused on analysing chromatin and the Polycomb complex in Ewing Sarcoma. Additionally, she has introduced the latest genomic technologies in the group to obtain the best resolution to different problems. She is a Research Associate and leads different translational projects that reach therapy from a deep understanding of the deregulation of molecular mechanisms associated with chromatin. Her main goal is to propose new treatments for those patients with Ewing Sarcoma with a worse prognosis. She is a co-director of 4 doctoral theses and has participated in different projects and congresses nationally and internationally.
Last Publications
- Figuerola-Bou E, Rios-Astorch C, Blanco E, Sanchez-Jimenez M, Táboas-Outón P, Fernandez-Isern G, Gomez-Gonzalez S, Muñoz-Aznar O, Castellano P, Pérez-Jaume S, Prada-Varela E, Mateo-Lozano S, Riggi N, Avgustinova A, Lavarino C, Di Croce L, Sánchez-Molina S and Mora J KDM6 demethylases mediate EWSR1-FLI1-driven oncogenic transformation in Ewing Sarcoma Biorxiv . : .
- Sánchez-Molina S, Figuerola-Bou E, Sánchez-Margalet V, de la Cruz-Merino L, Mora J, de Álava Casado E, García-Domínguez DJ and Hontecillas-Prieto L Ewing Sarcoma Meets Epigenetics, Immunology and Nanomedicine: Moving Forward into Novel Therapeutic Strategies Cancers . 14(21): .
- Molnar C, Reina J, Herrero A, Heinen JP, Méndiz V, Bonnal S, Irimia M, Sanchez-Jimenez M, Sánchez-Molina S, Mora J and González C Human EWS-FLI protein recapitulates in Drosophila the neomorphic functions that induce Ewing sarcoma tumorigenesis PNAS Nexus . 1(4): 222.
Projects
- Project name:
- SGR 2022-2024_Grup de recerca en tumors del desenvolupament
- Leader
- Jaume Mora Graupera
- Funding entities:
- Agaur - Agència de Gestió d'Ajuts Universitaris i de Recerca
- Code
- 2021 SGR 01612
- Starting - finishing date:
- 2022 - 2025
- Project name:
- Influencia del contexto epigenético en la edad como factor pronóstico en Ewing Sarcoma
- Leader
- Jaume Mora Graupera
- Funding entities:
- Instituto de Salud Carlos III (ISCIII)
- Code
- PI20/00179
- Starting - finishing date:
- 2021 - 2023
- Project name:
- SGR 2017_Grup de Recerca en tumors del desenvolupament
- Leader
- Jaume Mora Graupera
- Funding entities:
- Agaur - Agència de Gestió d'Ajuts Universitaris i de Recerca
- Code
- 2017 SGR 01672
- Starting - finishing date:
- 2017 - 2021
News
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Scientists at IRSJD and IRB Barcelona develop a study model for Ewing sarcoma in the Drosophila fly
This novel model has come about from a close collaboration between the laboratories headed by Dr. Jaume Mora at Institut de Recerca Sant Joan de Déu (IRSJD) and SJD Barcelona Children’s Hospital, and Dr. Cayetano Gonzalez at the Institute for Research in Biomedicine (IRB Barcelona). The work has been published in the journal PNAS Nexus.
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Describe an epigenetic protein associated with the metastatic process in Ewing's Sarcoma
A study with Dr. Jaume Mora (IRSJD) team participation and led by the Molecular Pathology of Sarcomas group of the Seville Institute of Biomedicine (IBiS) has described that the G9a protein would be associated with the development of metastases in Ewing's Sarcoma. Therefore, the overexpression of this protein would indicate an adverse prognosis.
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Gene crucial for growth of Ewing sarcoma uncovered
Researchers at the Institut de Recerca Sant Joan de Déu in collaboration with those at Centre for Genomic Regulation have discovered that RING1B is a critical gene for the development of Ewing sarcoma, a rare type of developmental cancer that presents in bones and soft tissues.