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Laia Alsina Manrique de Lara

Laia Alsina Manrique de Lara

Jefe de Grupo

Research group

Study of Immune Deficiency Diseases in Paediatrics (GEMDIP)

Researcher Laia Alsina graduated in Medicine in 2000 from the University of Barcelona, and he obtained a specialization in Paediatrics in 2004 at the Hospital San Juan de Dios Barcelona. She obtained her PhD degree from the University of Barcelona, in 2008.

Between 2008 and 2010 he completed a postdoctoral stay at the Baylor Institute for Immunology Research in Dallas, where he studied the immune pathways related to primary immunodeficiencies.

In 2018, she was appointed Head of the Unit of Clinical Immunology and Primary Immunodeficiencies of the SJD Barcelona Children's Hospital ​​and coordinated the Unit of Clinical Immunology between the Clinical Hospital and Sant Joan de Déu.

She is an Associate Professor at the University of Barcelona, since 2018.

She currently co-leads the Study Group of Diseases for Immune Dysfunction in Paediatrics (GEMDIP) where he studies the pathways affected in different forms of primary immunodeficiency, and how to apply this knowledge in personalized therapies in patients with diseases due to immune dysfunction, as well as the impact on the childhood immune system of various immunosuppressive therapies.

laia.alsina@sjd.es

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Last Publications

  • He T, Wang J, Carpio Tumba M, Wang S, Luo Y, Chen J, Li G, Shu Z, Zhang S, Stone DL, Huang Y, Lv Q, Xiong W, Wang J, Yu Z, Cuff CV, Kairis E, Kethri A, Towheed A, Goyette K, Karri U, Wang J, Liu C, Romeo T, Alsina L, Rosenberg DL, Clemente D, López-Robledillo JC, Rong Z, Zhao X, Jiang L, Aldave-Becerra JC, Muñoz-Urribarri AB, Oommen PT, Campbell-Stokes P, Zhu M, Liu P, Guo L, Xu Y, Yu Z, Tong H, Qiu X, Zhang Y, Chen H, Zhang C, Ou J, Liu C, Liu J, Shen Y, Cao J, Zhang X, Yang K, Bao Y, Li Z, Cao J, Duan Y, Liu F, Shi B, Sun M, Ma L, Chen Y, Yang W, Han X, Ma S, Luo J, Gu W, Yu G, Shi W, Zhao R, Sun L, Li W, An Y, Tang X, Zhao X, Han T, Ma J, Li Y, Piao Y, Sun F, Zhang D, Yin M, Zheng S, Li T, Niu H, Lin L, Mei S, Zhou F, Yang S, Li D, Yan M, Zeng H, Zeng P, Zheng W, Li X, Li X, Liu Y, Huang L, Yu H, Fan Z, Shen M, Lu M, Fang Z, Rimland CA, Song H, Peterson LW, Yousuf Al-Nesf MA, Aqel S, Mudawi DS, Raje N, Slowik V, Harris JG, Snyder B, Scheffler-Mendoza S, Yamazaki-Nakashimada MA, Cooper MA, Lau YL, Cetin Gedik K, Wang W, Ying W, Hou J, Zhou Q, Sun B, Sun J, Wang X, Ombrello AK, Huang Y, Wu HL, Sun L, Mao H, Yu X, Liu Z, Aksentijevich I, Kastner DL, Schwartz DM, Yang J and Zhou Q Multicenter international cohort study of haploinsufficiency of A20 reveals novel genetic architecture and phenotypic evolution. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY . 157(6): 1395-1410.
  • Tachó-Piñot R, Bashour H, Filipska M, Corral-Vazquez C, Guzman M, Marcos-Fa X, Martinuzzi D, Honner H, Canales Herrerias P, Tejedor Vaquero S, Sáez Gordón A, Perera-Bel J, Domínguez Barragán J, Arcos-Ribas B, de Campos-Mata L, Slabodkin A, Chernigovskaya M, Rodríguez de la Concepción ML, Gutierrez-Marcos J, García-García AP, Nascimento-Osorio A, Pascal M, Yagüe-Ribes J, Juan-Otero M, Arostegui-Gorospe JI, Hijano Esqué R, Sánchez Font A, Ehl S, Grimbacher B, Rizzi M, Dotta L, Chen K, Badolato R, Alsina L, Mehandru S, Cunningham-Rundles C, Carrillo J, Magri G, Greiff V and Cerutti A IgD from atypical-like memory B cells and plasma cells targets commensal and environmental antigens JOURNAL OF EXPERIMENTAL MEDICINE . 223(5): .
  • Vatovec T, Neehus AL, Jackson KJL, Avery DT, Bagaric I, Erazo L, Arango-Franco CA, Ogishi M, Ahmed SF, Cederholm A, Russell AJ, Della Mina E, Al-Rifai D, Bull R, Buetow L, Sobrino S, Zhang A, Wahlster L, Michelet M, Parvaneh N, Peel J, Barzaghi F, Leardini D, Philippot Q, Saettini F, Dutrieux J, de Muylder B, Vendemini F, Baccelli F, Català-Temprano A, Gambineri E, Veltroni M, Pandiarajan V, Aguilar Y, Haerynck F, Elliott M, Turville S, Brillot F, Khan T, Consonni F, Berteloot L, Sewell WA, Rao G, Largeaud L, Conti F, Roullion C, Masson C, Pegoraro F, Ye T, Joubran S, Villalpando E, Bessot B, Seeleuthner Y, Le Voyer T, Rosain J, Li H, Janda Z, Muratore E, Soudée C, Delabesse E, Goulvestre C, Shahrooei M, Puel A, André I, Bole-Feysot C, Abel L, Erlacher M, Béziat V, Lagresle-Peyrou C, Cheynier R, Six E, Marr N, Pasquet M, Alsina L, Goodnow CC, Landegren N, Aiuti A, Zhang P, Masetti R, Huang DT, Ma CS, Casanova JL, Sankaran VG, Bustamante J, Tangye SG and Bohlen J Somatic deficiency of the human E3 ubiquitin ligase CBL in leukocytes impairs B cell but not T cell development and function. NATURE IMMUNOLOGY . 27(2): 308-322.
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Projects

Project name:
Ensayo clínico fase Ib multicéntrico, exploratorio, abierto, no-aleatorizado y prospectivo, basket trial, con células CAR-T anti-CD19 (ARI-0001) en pacientes pediátricos con enfermedades autoinmunes sistémicas.
Leader
Jordi Antón López, Susana Rives Solà
Funding entities:
Instituto de Salud Carlos III (ISCIII)
Code
ICI25/00025
Starting - finishing date:
2026 - 2029
Project name:
ADVANCED THERAPIES (RICORS-TERAV)
Leader
Susana Rives Solà
Funding entities:
Instituto de Salud Carlos III (ISCIII)
Code
RD24/0014/0006
Starting - finishing date:
2025 - 2027
Project name:
Impacto de la exposición intrauterina a fármacos inmunomoduladores en el desarrollo del sistema inmunológico del recién nacido:estudios in vivo y desarrollo de organoides. Estudio NEWborn-IMM-PACT.
Leader
Laia Alsina Manrique de Lara
Funding entities:
Instituto de Salud Carlos III (ISCIII)
Code
PI24/00467
Starting - finishing date:
2025 - 2027
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