Research / Announcements Projectes de recerca

Accelerating Drug Discovery for Frontotemporal Degeneration


Announcement "closed"
Organization:
Alzheimer's Drug Discovery Foundation
Scope:
International
Start:
Internal deadline:
Official deadline:
Description:

Description

The Alzheimer's Drug Discovery Foundation (ADDF) funds drug discovery and development research programs in the field of Alzheimer's disease (AD), related dementias and cognitive aging. The ADDF seeks to fill the critical translational funding gap between basic research and later stage drug development by funding promising drug discovery and development programs. In addition to funding academic programs, the ADDF also invests in and creates early stage biotechnology companies. The ADDF also co-sponsors conferences to stimulate new ideas and approaches in areas of interest to the Foundation.

Main characteristics

Research investigating the pathogenic mechanisms underlying frontotemporal degeneration (FTD) is advancing, creating new targets for drug discovery. However, there remains a global gap in FTD drug discovery research. The Alzheimer's Drug Discovery Foundation (ADDF) and The Association for Frontotemporal Degeneration (AFTD) seek to accelerate and support innovative small molecule and biologic (antibodies, oligonucleotides, peptides, gene therapy) drug discovery programs for FTD through this request for proposals (RFP).

Priority areas for this program include:

  • Lead optimization of novel disease-modifying compounds, including medicinal chemistry refinement and in vitro ADME.
  • Testing of novel lead compounds, biologics, or repurposed drug candidates in relevant animal models for in vivo pharmacokinetics, dose-range finding, target engagement, in vivo efficacy, and/or preliminary rodent tolerability studies.

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    Funding

    Budgets averaging $100,000-$150,000 are recommended.

    Average duration: 1 year

    Terms

    In case of interest, please contact with Research Management Department until 6th July 2018.

    More information at: https://www.alzdiscovery.org/research-and-grants/funding-opportunities/accelerating-drug-discovery-for-ftd

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