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Guillem Pascual Pastó

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Publications

  • Giudice AM, Matlaga S, Roth SL, Gladney W, Groff D, Hofmann TJ, McDaid KS, Pascual-Pastó G, McIntyre B, Zecchino V, Martinez D, Spear TT, Wolpaw AJ, Assenmacher CA, Radaelli E, Pogoriler J, Pawel B, Barrett D, Grupp SA, Maris JM and Bosse KR.

    D3-GPC2-Directed CAR T Cells Are Safe and Efficacious in Preclinical Models of Neuroblastoma and Small Cell Lung Cancer.

    CLINICAL CANCER RESEARCH . 31(24): 5276-5293.

    [doi:10.1158/1078-0432.CCR-25-0089]

  • Giudice AM, Matlaga S, Roth SL, Pascual-Pastó G, Schürch PM, Rouin G, McIntyre B, Grothusen GP, Cresswell-Clay E, Shraim R, Groff D, Zecchino V, Lombardi S, Martinez D, Spruce LA, Brown EM, Fazelinia H, Henrickson SE, Nance J, Reynolds CP and Bosse KR.

    Target antigen-displaying extracellular vesicles boost CAR T cell efficacy in cell and mouse models of neuroblastoma.

    Science Translational Medicine . 17(825): .

    [doi:10.1126/scitranslmed.ads4214]

  • Giudice AM, Roth SL, Matlaga S, Cresswell-Clay E, Mishra P, Schürch PM, Boateng-Antwi KAM, Samanta M, Pascual-Pastó G, Zecchino V, Spear TT, McIntyre B, Chada NC, Wang T, Liu L, Wang R, Wilson JT, Wolpaw AJ and Bosse KR.

    Reprogramming the neuroblastoma tumor immune microenvironment to enhance GPC2 CAR T cells.

    MOLECULAR THERAPY . 33(9): 4552-4569.

    [doi:10.1016/j.ymthe.2025.05.025]

  • Strijker JGM, Pascual-Pastó G, Grothusen GP, Kalmeijer YJ, Kalaitsidou E, Zhao C, McIntyre B, Matlaga S, Visser LL, Barisa M, Himsworth C, Shah R, Muller H, Schild LG, Hains PG, Zhong Q, Reddel RR, Robinson PJ, Catena X, Soengas MS, Margaritis T, Dekker FJ, Anderson J, Molenaar JJ, Bosse KR, Wu W and Wienke J.

    Blocking MIF secretion enhances CAR T-cell efficacy against neuroblastoma.

    EUROPEAN JOURNAL OF CANCER . 218: 115263-115263. Number of citations: 14

    [doi:10.1016/j.ejca.2025.115263]

  • Pascual-Pastó G, McIntyre B, Hines MG, Giudice AM, Garcia-Gerique L, Hoffmann J, Mishra P, Matlaga S, Lombardi S, Shraim R, Schürch PM, Yarmarkovich M, Hofmann TJ, Alikarami F, Martinez D, Tsang M, Gil-de-Gómez L, Spear TT, Bernt KM, Wolpaw AJ, Dimitrov DS, Li W and Bosse KR.

    CAR T-cell-mediated delivery of bispecific innate immune cell engagers for neuroblastoma.

    Nature Communications . 15(1): 7141-7141. Number of citations: 23

    [doi:10.1038/s41467-024-51337-2]

  • Pascual-Pastó G, McIntyre B, Giudice AM, Alikarami F, Morrissey A, Matlaga S, Hofmann TJ, Burgeño-Sandoval V, Harvey K, Martinez D, Shah AC, Foster JB, Pogoriler J, Eagle RC, Carcaboso AM, Shields CL, Leahey AM and Bosse KR.

    Targeting GPC2 on Intraocular and CNS Metastatic Retinoblastomas with Local and Systemic Delivery of CAR T Cells

    CLINICAL CANCER RESEARCH . 30(16): 3578-3591. Number of citations: 12

    [doi:10.1158/1078-0432.CCR-24-0221]

  • Aschero MR, Ganiewich D, Lamas G, Restrepo-Perdomo CA, Ottaviani D, Zugbi S, Camarero S, Néspoli E, Cuadrado-Vilanova M, Pérez-Jaume S, Pascual-Pastó G, Sampor C, Grigorovski N, Salas B, Suñol M, Carcaboso AM, Mora J, de Dávila MTG, Doz F, Radvanyi F, Abramson DH, Llera AS, Schaiquevich PS, Lubieniecki F and Chantada G.

    Immunohistochemical expression of TFF1 is a marker of poor prognosis in retinoblastoma

    PEDIATRIC BLOOD & CANCER . 71(1): . Number of citations: 8

    [doi:10.1002/pbc.30717]

  • Pascual-Pastó G, Resa-Parés C, Castillo H, Aschero MR, Baulenas-Farrés M, Vilà-Ubach M, Burgeño-Sandoval V, Balaguer-Lluna L, Cuadrado-Vilanova M, Gene-Olaciregui N, Martinez N, Pérez-Jaume S, de Alava, E, Tirado, OM, Lavarino C, Mora J and Carcaboso AM.

    Low Bcl-2 is a robust biomarker of sensitivity to nab-paclitaxel in Ewing sarcoma.

    BIOCHEMICAL PHARMACOLOGY . 208: 115408-115408. Number of citations: 10

    [doi:10.1016/j.bcp.2022.115408]

  • Cuadrado-Vilanova M, Burgeño-Sandoval V, Balaguer-Lluna L, Aschero MR, Castillo H, Liu, J, Pérez-Jaume S, Pascual-Pastó G, Gene-Olaciregui N, Gomez-Gonzalez S, Correa, G, Suñol M, Schaiquevich, P, Radvanyi, F, Lavarino C, Mora J, Català-Mora J, Chantada G and Carcaboso AM.

    Follow-up of intraocular retinoblastoma through the quantitative analysis of conserved nuclear DNA sequences in aqueous humor from patients

    Journal of Pathology Clinical Research . 9(1): 32-43. Number of citations: 6

    [doi:10.1002/cjp2.296]

  • Bosse KR, Giudice AM, Lane MV, McIntyre B, Schürch PM, Pascual-Pastó G, Buongervino SN, Suresh S, Fitzsimmons A, Hyman A, Gemino-Borromeo M, Saggio J, Berko ER, Daniels AA, Stundon J, Friedrichsen M, Liu X, Margolis ML, Li MM, Tierno MB, Oxnard GR, Maris JM and Mossé YP.

    Serial Profiling of Circulating Tumor DNA Identifies Dynamic Evolution of Clinically Actionable Genomic Alterations in High-Risk Neuroblastoma.

    Cancer Discovery . 12(12): 2800-2819. Number of citations: 42

    [doi:10.1158/2159-8290.CD-22-0287]