The European Partnership for Brain Health (EP BrainHealth), a collaborative initiative co-funded under Horizon Europe, aims to advance scientific knowledge on biological, social and environmental factors that influence brain health throughout the life-course. This Joint Transnational Call (JTC2026 Call 2) focuses on research addressing how these factors impact the trajectory of neurodegenerative disorders across the lifespan. The call invites multinational, interdisciplinary and translational research consortia to investigate mechanisms, early recognition/diagnosis/prognosis, prevention, treatments, interventions, care and support linked to these factors and their impact on neurodegenerative disease outcomes. Proposals should address at least two factor categories (biological, lifestyle/social, environmental) and at least two research aspects among mechanisms, diagnostics/prognostics and interventions linked to relevant factors, with clear potential benefit for patients and carers. Applications must be interdisciplinary and translational, integrating holistic and in-depth biological insights to address critical questions in neurodegeneration research.

• Call opening date: 8 January 2026 (call opens the same date as other 2026 JTCs)

• Pre-proposal submission deadline: 10 March 2026, 14:00 Berlin time

• Full proposal submission deadline: 30 June 2026, 14:00 CEST

• Date of publication: Not clearly specified in the available call text

Eligibility / Criteria

• Joint transnational research projects must be submitted by consortia including a minimum of three research partners from three different participating countries, with at least two partners from EU Member States or Horizon Europe Associated Countries.

• Projects must be novel, hypothesis-driven, interdisciplinary and translational with well-structured work plans and deliverable objectives within a maximum of 3 years.

• Proposals must address neurodegenerative disorders and investigate how biological, lifestyle/social and environmental factors affect their trajectory.

• Research must investigate at least two factor categories and at least two research aspects among mechanisms, early recognition/diagnosis/prognosis and prevention/treatments/interventions/technological development/care and support.

• Applicants must comply with ethical, legal and national regulations, including obtaining necessary approvals where applicable.

• Specific eligibility and funding conditions depend on national/regional funding organisations participating in the call and must be checked individually

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