Investigación / Convocatorias Projectes de recerca

Improving Health Decision Making With Comparative Clinical Effectiveness Research PCORI


Convocatoria "abierta"
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Entidad convocante:
The Patient-Centered Outcomes Research Institute (PCORI)
Categoría:
Projectes de recerca
Ámbito:
Internacional
Inicio:
Plazo interno:
Plazo real:
Cuantía:
Up to $2,000,000
Descripción:

  • Introduction The Patient-Centered Outcomes Research Institute (PCORI) plans to issue this funding announcement to support patient-centered comparative clinical effectiveness research (CER). ​​

  • General description: PCORI seeks well-designed, methodologically robust retrospective observational CER studies that leverage established, ready-to-use data sources (e.g., PCORnet) to generate timely, impactful, patient-centered evidence for healthcare decision making. Studies should compare existing interventions that pose current decisional dilemmas and have robust efficacy evidence or are in widespread use. Both clinical interventions (e.g., medications, diagnostic tests, procedures) and delivery-system interventions (e.g., workforce, technologies, service delivery designs) are within scope. This is a two-stage process (LOI followed by full application). ​​​

  • Objectives: To produce timely, impactful, and patient-centered results that inform healthcare decisions and improve health outcomes through retrospective observational CER using existing data sources. ​​

  • Thematic areas: Applications must address at least one PCORI-approved Topic Theme: cancer; pain; substance use; maternal morbidity and mortality; intellectual and developmental disabilities; sensory health; metabolic and endocrine health; mental and behavioral health; or rare diseases. ​

  • Deadline

    • PFA opens: December 2, 2025 ​​
    • Applicant Town Hall: December 10, 2025, 12:00 pm (ET) ​
    • Letter of Intent (LOI) deadline: January 6, 2026; 5:00 pm (ET) ​
    • LOI status notification: February 3, 2026 ​​
    • Full application deadline: May 5, 2026; 5:00 pm (ET) ​​
Requisitos
  • Study design: Retrospective observational, patient-centered CER leveraging established, ready-to-use data sources (e.g., PCORnet). ​​​
  • Interventions: Must compare existing interventions that represent current decisional dilemmas and have robust efficacy evidence or are widely used. ​​
  • Topic alignment: Must explicitly address at least one of PCORI's Topic Themes listed above; otherwise, applications will be considered nonresponsive. ​​
  • Data readiness: Only existing, ready-to-analyze data are eligible; establishing new data networks/registries/linkages is not supported. ​​
  • Other standard applicant/institutional eligibility details are not specified in the preannouncement and will be provided in the full PFA. ​
Splicitud

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